Books
This page contains books specifically about HIV/AIDS and pregnancy as well as more general materials.
Scientific Basis of Healthcare: AIDS and Pregnancy.
Author/ Year: Martin, C. R., & Preedy, V. R. (Eds.) / 2011
Publisher: Science Publishers.
" This volume on AIDS & Pregnancy covers prenatal assistance, antenatal care and screening, treatment for low lymphocyte count, antiretroviral regimes for prevention of transmission to child, adverse effects of antiretroviral therapy in pregnancy, awareness of HIV on pregnancy, occupational hazards and so on. The series is designed for student nurses, practicing healthcare workers, qualified nurses and healthcare practioners, post graduates, special project students, teachers, lecturers and professors of nursing and healthcare. It is also suitable for college, university or nursing school libraries as a reference guide." - Retrieved from CRCPress.com
Publisher: Science Publishers.
" This volume on AIDS & Pregnancy covers prenatal assistance, antenatal care and screening, treatment for low lymphocyte count, antiretroviral regimes for prevention of transmission to child, adverse effects of antiretroviral therapy in pregnancy, awareness of HIV on pregnancy, occupational hazards and so on. The series is designed for student nurses, practicing healthcare workers, qualified nurses and healthcare practioners, post graduates, special project students, teachers, lecturers and professors of nursing and healthcare. It is also suitable for college, university or nursing school libraries as a reference guide." - Retrieved from CRCPress.com
Mechanisms by which pregnancy increases the clearance of the anti-HIV protease inhibitor, nelfinavir.
Author/Year: Zhang, H. / 2011
Publisher: ProQuest
"Given standard doses, pregnant women achieve lower plasma concentrations of anti-HIV protease inhibitors (PIs) than non-pregnant women or men. The goal of this research was to determine the mechanistic basis of this phenomenon by using a representative animal model. Therefore, we investigated two animal models, the non-human primate, M. nemestrina and the mouse, including the CYP3A4-promoter-lucficerase-transgenic mouse. We first tested and showed that the oral clearance of nelfinavir, a PI, was significantly increased (∼3-fold) in the pregnant macaque. This increased oral clearance was caused by increased systemic clearance (1.9-fold) and decreased bioavailability (∼45%) of the drug during pregnancy. In vitro studies showed that pregnancy significantly increased the rate of nelfinavir depletion in hepatic, but not intestinal S-9 fractions. These data suggested that increased hepatic activity of nelfinavir metabolizing enzymes (perhaps CYP3A enzymes) results in increased clearance of PIs during pregnancy in the macaque. Because nelfinavir is cleared from the body predominantly by CYP3A and P-glycoprotein, we studied, if pregnancy affects the intestinal and hepatic CYP3A activity in M. nemestrina, using midazolam as a probe, and intestinal, hepatic and renal P-gp activity, using digoxin as a probe. Although systemic clearance of midazolam was significantly increased during pregnancy (perhaps due to increased hepatic blood flow), no significant difference in the oral clearance of the drug was observed. In vitro studies found no change in hepatic or intestinal CYP3A activity or expression during pregnancy. In addition, no change in digoxin pharmacokinetics was observed during pregnancy, indicating unchanged P-glycoprotein activity. Therefore, the activity of some other transporter(s) and/or enzyme(s), involved in the clearance of nelfinavir, must be increased during macaque pregnancy. Though our macaque studies did not suggest that CYP3A activity was increased during pregnancy, our mouse studies do. We found that transcriptional activation of selective CYP3a isoforms leads to increased expression and activity of CYP3a in the pregnant mouse. That is, the pregnancy-related factors that transcriptionally activate mouse Cyp3a isoforms also activate the human CYP3A4 promoter in pregnant CYP3A4-promoter-luciferase-transgenic mice. We propose that the CYP3A4-promoter-luciferase-transgenic mouse should be studied to determine the molecular mechanisms of increased CYP3A activity during pregnancy." - Retrieved from Amazon.com
Publisher: ProQuest
"Given standard doses, pregnant women achieve lower plasma concentrations of anti-HIV protease inhibitors (PIs) than non-pregnant women or men. The goal of this research was to determine the mechanistic basis of this phenomenon by using a representative animal model. Therefore, we investigated two animal models, the non-human primate, M. nemestrina and the mouse, including the CYP3A4-promoter-lucficerase-transgenic mouse. We first tested and showed that the oral clearance of nelfinavir, a PI, was significantly increased (∼3-fold) in the pregnant macaque. This increased oral clearance was caused by increased systemic clearance (1.9-fold) and decreased bioavailability (∼45%) of the drug during pregnancy. In vitro studies showed that pregnancy significantly increased the rate of nelfinavir depletion in hepatic, but not intestinal S-9 fractions. These data suggested that increased hepatic activity of nelfinavir metabolizing enzymes (perhaps CYP3A enzymes) results in increased clearance of PIs during pregnancy in the macaque. Because nelfinavir is cleared from the body predominantly by CYP3A and P-glycoprotein, we studied, if pregnancy affects the intestinal and hepatic CYP3A activity in M. nemestrina, using midazolam as a probe, and intestinal, hepatic and renal P-gp activity, using digoxin as a probe. Although systemic clearance of midazolam was significantly increased during pregnancy (perhaps due to increased hepatic blood flow), no significant difference in the oral clearance of the drug was observed. In vitro studies found no change in hepatic or intestinal CYP3A activity or expression during pregnancy. In addition, no change in digoxin pharmacokinetics was observed during pregnancy, indicating unchanged P-glycoprotein activity. Therefore, the activity of some other transporter(s) and/or enzyme(s), involved in the clearance of nelfinavir, must be increased during macaque pregnancy. Though our macaque studies did not suggest that CYP3A activity was increased during pregnancy, our mouse studies do. We found that transcriptional activation of selective CYP3a isoforms leads to increased expression and activity of CYP3a in the pregnant mouse. That is, the pregnancy-related factors that transcriptionally activate mouse Cyp3a isoforms also activate the human CYP3A4 promoter in pregnant CYP3A4-promoter-luciferase-transgenic mice. We propose that the CYP3A4-promoter-luciferase-transgenic mouse should be studied to determine the molecular mechanisms of increased CYP3A activity during pregnancy." - Retrieved from Amazon.com
Essentials of Management of Pregnancy in HIV-Infected Women:
A Handbook for Obstetricians and Gynecologists (Dr. Malhotra's Series).
Author/Year: Vashishta, A. / 2008
Publisher: Jaypee Brothers, Medical Publishers
"The field of medicine, especially HIV/AIDS, is ever-changing and has become increasingly complex. Pregnancy in HIV- infected women is a special situation because it provides a unique opportunity for prevention of vertical transmission of HIV using various interventions. - The mgmt of HIV-infected pregnant women had become increasingly complex especially with the advent of highly active antiretroviral therapy. This book is an honest attempt to provide the Latest information in the field of HIV and pregnancy in a comprehensible format. - Indudes several real-life case studies about HIV-infected pregnant women and this appropriate mgmt." - Retrieved from Books.Google.com
Publisher: Jaypee Brothers, Medical Publishers
"The field of medicine, especially HIV/AIDS, is ever-changing and has become increasingly complex. Pregnancy in HIV- infected women is a special situation because it provides a unique opportunity for prevention of vertical transmission of HIV using various interventions. - The mgmt of HIV-infected pregnant women had become increasingly complex especially with the advent of highly active antiretroviral therapy. This book is an honest attempt to provide the Latest information in the field of HIV and pregnancy in a comprehensible format. - Indudes several real-life case studies about HIV-infected pregnant women and this appropriate mgmt." - Retrieved from Books.Google.com
HIV in Pregnancy and Childbirth, Second Edition
Author/Year: Kennedy, J. / 2003
Publisher: Books for Midwives
"This practical guide addresses the issues of HIV infection and its implications for both the pregnant woman and the midwife. It covers epidemiology, transmission, the disease progress, and the provisions of holistic pregnancy care." -Retrieved from Amazon.com
Publisher: Books for Midwives
"This practical guide addresses the issues of HIV infection and its implications for both the pregnant woman and the midwife. It covers epidemiology, transmission, the disease progress, and the provisions of holistic pregnancy care." -Retrieved from Amazon.com
Theraputic Drug Monitoring: Newer Drugs and Biomarkers
Author/Year: Dasqupta, A. (Ed.). / 2012
Publisher: Academic Press
"Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring." -Retrieved from Amazon.com
Publisher: Academic Press
"Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring." -Retrieved from Amazon.com
Women's Health Review: A Clinical Update in Obstetrics - Gynecology
Author/Year: DiSaia, P. J., et al. / 2012
Publisher: Elsevier Health Sciences
"The latest clinical recommendations, developments, and procedures are now available with Women's Health Review. This comprehensive, yet succinct summary is an up to date medical reference book – a product of the collaboration between leading physicians and scientists from University of California medical schools. Zero in on the most important new information with "update boxes," and dig deeper into the surrounding text for more background or complementary discussions. Review key points quickly with the aid of relevant tables and images.Take an organized approach to review with a subspecialty-based structure and a convenient outline format." -Retrieved from obgyn.ucsf.edu
Publisher: Elsevier Health Sciences
"The latest clinical recommendations, developments, and procedures are now available with Women's Health Review. This comprehensive, yet succinct summary is an up to date medical reference book – a product of the collaboration between leading physicians and scientists from University of California medical schools. Zero in on the most important new information with "update boxes," and dig deeper into the surrounding text for more background or complementary discussions. Review key points quickly with the aid of relevant tables and images.Take an organized approach to review with a subspecialty-based structure and a convenient outline format." -Retrieved from obgyn.ucsf.edu
Updated 2012 by Peace Ossom